NAD+ is a coenzyme found in all living cells and is essential for energy metabolism, DNA repair, and cellular health. Levels of NAD+ naturally decline with age, stress, and illness, contributing to aging and various chronic diseases. Supplementing NAD+ via subcutaneous injection is one method to restore its levels in the body.

1. Energy Metabolism

   • NAD+ is a key player in cellular energy production. It facilitates the transfer of electrons in oxidative phosphorylation and the Krebs cycle, generating ATP, the energy currency of the cell.

2. Sirtuin Activation

   • Sirtuins are NAD+-dependent enzymes involved in regulating cellular processes like aging, inflammation, and mitochondrial function. Increased NAD+ levels enhance sirtuin activity, promoting better cellular repair and longevity.

3. DNA Repair

   • NAD+ is a substrate for enzymes like PARPs (poly-ADP-ribose polymerases), which repair DNA damage. Adequate NAD+ levels are critical for maintaining genomic stability.

4. Reduction of Oxidative Stress

   • NAD+ plays a role in regenerating antioxidants like glutathione and reducing oxidative damage.

5. Mitochondrial Health

   • By boosting NAD+ levels, cells can maintain optimal mitochondrial function, which is critical for energy production and metabolic health.

1. Salvage Pathway

   • Most NAD+ in the body is recycled through the salvage pathway, which converts nicotinamide (a breakdown product of NAD+) back into NAD+.

2. De Novo Pathway

   • This pathway synthesizes NAD+ from tryptophan, but it is less efficient than the salvage pathway.

3. Exogenous Supplementation

   • Subcutaneous NAD+ injections bypass the digestive system, delivering NAD+ directly into the bloodstream for cellular uptake.

1. Increased Energy Levels

   • Enhances ATP production, reducing fatigue and boosting physical performance.

2. Improved Cognitive Function

   • May support brain health by repairing neuronal damage and improving neurotransmitter balance.

3. Anti-Aging Effects

   • Promotes DNA repair, reduces oxidative stress, and supports mitochondrial health to slow aging processes.

4. Enhanced Recovery

   • Assists in muscle recovery and repair post-exercise and supports recovery from cellular stress.

5. Support for Chronic Conditions

   • NAD+ supplementation is being explored for managing conditions like neurodegenerative diseases, diabetes, and chronic fatigue syndrome.

Chronic Fatigue and Low Energy

Constant exhaustion or lack of energy, even after a full night's sleep, can make it difficult to perform daily tasks or maintain an active lifestyle.

Cognitive Decline and Brain Fog

Mental clarity issues, memory lapses, and cognitive decline are common as people age, often leading to brain fog and decreased mental function.

Aging and Cellular Repair

As we age, cellular function declines, leading to wrinkles, reduced skin elasticity, and other signs of aging. The body’s natural repair mechanisms slow down over time.

Chronic Inflammation

Persistent inflammation is linked to a variety of chronic health conditions, such as heart disease, autoimmune diseases, and arthritis.

Poor Metabolism and Weight Management

Sluggish metabolism can contribute to difficulty losing weight, especially as one ages. Issues such as insulin resistance and decreased fat-burning ability may arise.

Mood Disorders and Mental Health Issues

Anxiety, depression, and stress can disrupt daily life and well-being. These mental health struggles can result from neurochemical imbalances or mitochondrial dysfunction.

Decreased Immune Function

As people age or experience chronic illness, their immune system may weaken, making them more susceptible to infections, illness, and poor recovery.

Cellular Repair and DNA Damage

DNA damage occurs naturally over time due to aging, environmental factors, or stress. The body’s ability to repair DNA decreases with age.

Heart Health and Cardiovascular Issues

Age-related cardiovascular issues such as heart disease, high blood pressure, and poor circulation can be exacerbated by mitochondrial dysfunction and oxidative stress.

Liver Health and Detoxification

Poor liver function or toxin buildup can lead to fatigue, digestive issues, and even liver disease.

In summary, NAD+ offers potential benefits for a wide range of health concerns, especially those related to aging, energy production, cognitive decline, metabolism, inflammation, and recovery. Whether you’re struggling with chronic fatigue, cognitive decline, poor metabolism, or stress, boosting NAD+ levels may provide significant support to help you regain energy, improve mental clarity, and enhance overall health.

1. General Guidelines

   • Initial Loading Phase: 250–500 mg per day, depending on individual needs and goals.

   • Maintenance Phase: 250 mg weekly or biweekly.

2. Administration

   • Subcutaneous injections are typically administered into fatty tissue, such as the abdomen or thigh.

   • Injections should be done slowly to minimize discomfort.

Dosing at 250 mg weekly will last 140 days. That is less than $4.3/day at the recommended dose.