Ipamorelin is a synthetic peptide that belongs to the class of growth hormone secretagogues (GHS). It is primarily used to stimulate the release of growth hormone (GH) from the pituitary gland.

Ipamorelin mimics the action of ghrelin, the body's natural growth hormone-releasing peptide (GHRP). However, it is selective in its activity, targeting only the growth hormone release without significantly affecting other hormones such as cortisol or prolactin.

• Binding to GHS-R1a: Ipamorelin binds to the growth hormone secretagogue receptor (GHS-R1a) on pituitary somatotrophs, which stimulates the release of GH.

• Inhibition of Somatostatin: It reduces the activity of somatostatin, a hormone that inhibits GH secretion, further amplifying GH release.

• Stimulates Ghrelin Pathways: Unlike ghrelin, ipamorelin is specific for GH release and doesn’t significantly increase appetite or promote fat storage.

1. Hypothalamus-Pituitary Axis: Ipamorelin works through the hypothalamus-pituitary axis to increase pulsatile GH release. This mimics the body’s natural rhythm, avoiding desensitization.

2. IGF-1 Stimulation: The increase in GH levels leads to the production of insulin-like growth factor 1 (IGF-1) in the liver, which mediates many of the anabolic and tissue-repair effects of GH.

Ipamorelin is valued for its role in anti-aging, recovery, and overall health optimization. Key benefits include:

1. Enhanced Recovery:

   • Stimulates tissue repair and regeneration.

   • Accelerates healing of injuries, particularly tendons and ligaments.

   • Improves recovery time after intense exercise.

2. Increased Lean Muscle Mass:

   • Promotes anabolic activity, supporting muscle growth.

   • Preserves lean muscle during weight loss.

3. Fat Loss:

   • Increases lipolysis (fat breakdown), promoting a leaner body composition.

   • Prevents muscle wasting while reducing body fat.

4. Improved Sleep:

   • Enhances deep sleep (slow-wave sleep), which is essential for recovery and cognitive function.

   • Boosts natural GH release during sleep cycles.

5. Anti-Aging Effects:

   • Supports collagen production, improving skin elasticity and reducing wrinkles.

   • Increases bone density over time, reducing osteoporosis risk.

6. Metabolic and Immune Support:

   • Enhances metabolism and energy levels.

   • Strengthens the immune system through improved tissue health and repair.

Aging and Appearance Concerns

• Visible signs of aging such as wrinkles, fine lines, and loss of skin elasticity.

• Reduced collagen production leading to sagging skin and dull complexion.

• Desire for a more youthful, radiant appearance.
  

Energy and Vitality

• Persistent fatigue and low energy levels.

• Struggles with maintaining mental clarity, focus, and motivation.

• Feeling drained or unproductive throughout the day.
  

Muscle Growth and Recovery

• Difficulty gaining or maintaining lean muscle mass.

• Slow recovery from workouts, leading to prolonged soreness.

• Reduced stamina and endurance for physical activities.
  

Weight Management

• Difficulty losing body fat, particularly in stubborn areas.

• Slower metabolism due to age or lifestyle factors.

• Frustration with ineffective diet and exercise regimens.
  

Sleep Issues

• Poor sleep quality, trouble falling or staying asleep.

• Feeling unrested even after a full night’s sleep.

• Sleep disruptions impacting energy and recovery.
  

Joint and Tissue Health

• Chronic joint pain or stiffness.

• Slow healing from injuries, surgeries, or strains.

• Decline in overall physical resilience with age.
  

Hormonal Decline

• Reduced growth hormone levels leading to lower vitality.

• Symptoms such as reduced muscle tone, increased fat accumulation, and decreased overall performance.

Ipamorelin addresses these pain points by naturally stimulating growth hormone production, promoting muscle growth, improving recovery, supporting fat loss, enhancing sleep, and restoring vitality and energy.

Ipamorelin is typically administered via subcutaneous (under the skin) injection.

Common Dosage Protocols:

• Standard Anti-Aging Dosage:

  • Dose: 200–300 mcg per injection.

  • Frequency: 1-3 times per day (morning, post-workout, and before bed for maximum GH pulsatility).

• Performance and Recovery Dosage:

  • Dose: 300–500 mcg per injection.

  • Frequency: 1-2 times per day, depending on recovery needs.

Cycle Duration:

• Typical Cycle: 8–12 weeks, followed by a break to avoid receptor desensitization.

• Stacking: Often combined with other peptides like CJC-1295 (without DAC) to amplify GH release.

Dosing at 200 mcg twice per day will last 125 days. That is only $3.6/day at the recommended dose.