Feel Younger, Live Better: The Science of NAD+

Key Findings from the Study on NAD+:

1. Central Role in Cellular Function:

   • NAD+ is crucial for redox reactions, energy metabolism, and as a cofactor for non-redox enzymes like sirtuins and PARPs.

   • It directly influences metabolic pathways, DNA repair, chromatin remodeling, immune function, and cellular senescence.

2. Age-Related Decline:

   • NAD+ levels decrease with age in humans and animal models, contributing to metabolic dysfunction, neurodegeneration, and chronic inflammation.

   • This decline is associated with increased susceptibility to age-related diseases such as cognitive decline, cancer, and cardiovascular disorders.

3. Therapeutic Potential:

   • Restoring NAD+ levels through precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) has shown promise in mitigating age-related diseases in preclinical studies.

   • NAD+ augmentation therapies could potentially extend healthspan and lifespan by countering metabolic and immune dysregulation.

4. Mechanistic Insights:

   • The study delves into how NAD+ metabolism impacts DNA repair, epigenetic regulation, and circadian rhythms.

   • Age-related increases in NAD+ consumption enzymes (e.g., PARPs, CD38) further accelerate its depletion.

5. Clinical Prospects:

   • Emerging strategies to boost NAD+ include lifestyle interventions, dietary supplements, and targeting consumption pathways with inhibitors.

   • More studies are needed to establish efficacy and safety in humans.